● Non-targeted Metabolomics (Discovery Metabolomics)
Based on liquid chromatography-mass spectrometry (LC-MS) technology, non-targeted metabolomics enables unbiased detection of as many small-molecule metabolites as possible in biological samples such as cells, tissues, organs, or body fluids. It conducts comparative analysis between experimental and control groups, screens differential metabolites through statistical analysis.
● Non-targeted Metabolomics for Lipids
Leveraging liquid chromatography-mass spectrometry (LC-MS) technology, non-targeted Metabolomics for Lipids achieves unbiased detection of as many lipid molecules as possible in biological samples including cells, tissues, organs, or body fluids.
● Wide-Targeted Metabolomics
This service perfectly combines the high-resolution and wide-coverage advantages of untargeted technology with the high sensitivity and accurate quantification capabilities of targeted MRM (Multiple Reaction Monitoring) technology. The workflow is as follows: First, high-resolution mass spectrometry is used to perform ultra-high-coverage MS² scanning on samples to obtain MS² spectra of "all" metabolites. Then, accurate metabolite identification is conducted by combining with a high-resolution MS² library (covering over 25,000 metabolites, with multiple standard high-resolution MS² spectra for each metabolite). Next, MRM ion pair information is extracted from the mass spectra to establish a specific library for samples. Finally, triple quadrupole mass spectrometry with MRM technology is applied for accurate quantification.
● Targeted Metabolomics
Targeted metabolomics focuses on several target compounds or all/partial metabolites involved in a specific pathway. Using standard substances, it establishes a detection method with strong specificity, high sensitivity, and good repeatability for the quantification and analysis of target compounds. It adopts external standard combined with internal standard for absolute quantification, with the linearity of the standard curve reaching over 0.99 and the sensitivity up to ng/mL level.
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